The Role of VDR Gene Polymorphisms in Vitamin D Supplementation

Virtual data rooms are secure storage space for documents that are used during business transactions, legal proceedings or IPOs. The VDR can be accessed via an exclusive Internet link that only allows authorized parties to access and edit information. Virtual data rooms are utilized by many companies in M&A transactions, because they offer a secure and safe way to exchange confidential documents.

The vitamin D receptor (VDR) is a nuclear transcriptional regulator that activates by binding to 1a,25-dihydroxycholecalciferol (1a,25(OH)2D), known as calcitriol, which forms a heterodimer with the retinoid X receptor (RXR). Calcitriol signalling is involved in a variety of biological effects that include the metabolic processes of calcium and phosphorous and parathormone release. It also plays a role in cell expansion and control of innate and adaptive immunity.

A T > C shift in the promoter region of the VDR variant (rs11568820) eliminates the binding site for transcription factor Cdx2 just upstream of exon 1. This leads to a smaller protein with decreased transcriptional activity. The F allele is present in high frequency among Asians and Europeans, and in lower frequency among Africans from Sub-Saharan Africa.

The findings of this study enhance our understanding of how VDR gene polymorphisms affect the reaction to dietary supplements that contain calcium calcitriol. Carriers of the TaqI polymorphism and the FF genotype of the FokI polymorphism have higher transcriptional activation of VDR and are associated with better calcium absorption and bone mineral density and a decrease in the risk of fractures [34 35, 34[34, 35]. Further research with more homogeneous designs is needed to improve our understanding of how these genetic variants influence vitamin D supplementation and its clinical significance.

Tags: No tags

Add a Comment

Your email address will not be published. Required fields are marked *